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    I was discussing the effect of population growth and the relation to new mt DNA mutations in Advanced topic of mt DNA.

    As I was reading several scientific papers, I noticed a fundamental flaw in calculating phylogenetic mutation rates when comparing it with how direct pedigrees mt DNA mutation rate is calculated.

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    This is calculated to be 3/705 = 0.0043 mutations per generation or 0.32/site/Mya or 6.4 x 10-6 substitutions per site per generation. My network team says that the IP is blocked from your side.Could you please unblock our access, as we are immensely dependant on your website for our queries.Conflicting Observations Many scientists do acknowledge that the direct verifiable pedigrees mtdna mutation rates are observed to be much higher in the order of 10 times compared to the phylogenetic mutation rates which are non-observable and has several assumptions.The real value of mutation rate in humans has recently been the subject of an intense debate between those advocating the use of a phylogenetic mutation rate (~3 x 10^-6 substitutions per site per generation of 20 yr) calibrated by the divergence between humans and chimpanzees (Jazin et al. Ref: Estimation of Past Demographic Parameters From the Distribution of Pairwise Differences When the Mutation Rates Vary Among Sites: Application to Human Mitochondrial DNA While the order of 10x times in observable mutation rates using direct pedigree is a serious blow to phylogenetic mutation rates, what I noticed is much more serious than it.

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